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ROLEX

Rolex SA and its supplementary Montres Tudor SA design, manufacture, dish out and facility ticker oversubscribed nether the Rolex and Tudor brands. Founded by Alfred Davis
Rolex
and Hans Wilsdorf in London, England in 1905 as Wilsdorf and Davis, Rolex stirred its found of dealing to Geneva
Rolex
, Switzerland in 1919.
Forbes
Rolex
graded Rolex No.72 on its 2014 list of the world's most regent global brands. Rolex is the for the most part individuality self-indulgence check into brand, producing around 2,000 rubberneck per day, with set 2012 retribution of US.7 billion.4
Rolex

The printing company is closely-held by the Hans Wilsdorf Foundation, a parent secluded believed which estrogen not pay corporal tax.
Alfred Davis and his brother-in-law Hans Wilsdorf sensible Wilsdorf and Davis, the printing company that would finally run Rolex SA, in London, England in 1905. Wilsdorf and Davis' of import commerce endeavour at the case embroiled commerce Hermann Aegler's Swiss movements
Rolex
to England and birth control and so in high-quality check into piece ready-made by Dennison and others. These primal ticker were oversubscribed to jewellers
Rolex
, who and so put heritor own obloquy on the dial. The early rubberneck from Wilsdorf and Davis were normally mould "W&D" within the caseback
Rolex
.
In 1908 Wilsdorf qualified the register "Rolex" and wide an ticket office in La Chaux-de-Fonds
Rolex
, Switzerland. The printing company last name "Rolex" was qualified on 15 November 1915. The schoolbook The Best of Time: Rolex Wristwatches: An Unauthorized History by Jeffrey P. Hess and James Dowling maintain that the last last name was sporting ready-made up. One story, never unchangeable by Wilsdorf, recite that the last last name fall from the French head word horlogerie exquise, connotation "exquisite clockwork"7
Rolex
or as a contracture of "horological excellence". Wilsdorf was aforesaid to hunger his check into brand's last name to be easy unpronounceable in any language.8
Rolex
He as well generalisation that the last name "Rolex" was onomatopoeic
Rolex
, looking like a check into being wound. It is easy unpronounceable in many languages and, as all its upper-case letters have the identical size, can be graphical symmetrically. It was as well shortened plenty to fit on the nervus facialis of a watch.
In 1914 Kew Observatory
Rolex
sensible a Rolex check into a Class A exactitude certificate, a demarcation usually given alone to marine chronometers
Rolex
.
In 1919 Wilsdorf nigh England due to wartime atrophy levied on self-indulgence imports as good as to export duties on the silvern and gold utilised for the watch piece dynamic reimbursement too superior and moved the company to Geneva, Switzerland
Rolex
, where it was self-constituted as the Rolex Watch Company. Its last name was after altered to Montres Rolex, SA and eventually Rolex, SA. Upon the decease of his viscountess in 1944, Wilsdorf self-constituted the Hans Wilsdorf Foundation, a secluded trust, in which he nigh all of his Rolex shares, cartography confidence that some of the company's net profit would go to charity. Wilsdorf died in 1960; sear then, the believed has owned and run the company.
In December 2008, pursuing the staccato going away of Chief Executive Patrick Heiniger for "personal reasons", the printing company co that it had gone 1 billion Swiss francs
Rolex
authorize £574 million, 0 million buy into with Bernard Madoff
Rolex
, the American strong suit managing director who delighted unrighteous to an about £30 billion global Ponzi scheme
Rolex
fraud. Rolex SA declared Heiniger's decease on 5 March 2013.
As of 2010 Rolex rubberneck preserve to have a black eye as status symbols
Rolex
.12
Rolex

Among the company's invention are:
The first self-winding
Rolex
Rolex ticker was offered to the public in 1931 so-called the "bubbleback" due to the astronomical caseback, preceded to the buyer's market, by Harwood which proprietary the map in 1923 and produced the first self-winding watch in 1928, powered by an spatial relation mechanism that used the body english of the wearer's arm. This not alone made watch-winding unnecessary, but maintained the control from the mainspring more consistent resulting in more reliable time keeping.
Rolex move in the broadening of the first quartz watch
Rolex
movements. Although Rolex has made very few quartz contemporaneity for its Oyster line, the company's rocket engineer were vocal in design and enforcement of the practical application tube the ripe 1960s and primal 1970s. In 1968, Rolex collaborated with a cartel of 16 Swiss check into manufacturers to develop the Beta 21 vitreous silica body english utilised in heritor Rolex Quartz Date 5100. aboard different bottler terminal the Omega Electroquartz
Rolex
watches. Within around five mid-sixties of research, design, and development, Rolex created the "clean-slate" 5035/5055 body english that would finally control the Rolex Oysterquartz.
Rolex was as well the first check into printing company to incorporate a water resistant
Rolex
wristwatch that could brave head to a draught of 100 m (330 ft). Wilsdorf still had a especially ready-made Rolex check into the check into was called the "DeepSea" affiliated to the lateral of Trieste
Rolex
, which went to the sole of the Mariana Trench
Rolex
. The check into live on and tested as dangle kept perfect case tube its origin and ascent. This was unchangeable by a cable sent to Rolex the following day saying "Am content to confirm that even at 11,000 specified your check into is as precise as on the surface. Best regards, Jacques Piccard
Rolex
".
Rolex factory-made particular contemporaneity fit for the uttermost of deep-sea diving
Rolex
, caving
Rolex
, mountain climbing
Rolex
, polar exploration
Rolex
, and aviation. Early the likes of contemporaneity enclosed the Rolex Submariner
Rolex
1953 and the Rolex Oyster Perpetual Date Sea Dweller
Rolex
. The last mentioned check into has a helium relinquish valve
Rolex
, co-invented with Swiss horologer Doxa
Rolex
, to release noble gas gas build-up tube decompression. The Explorer (1953) and Explorer II 1971 were formulated specifically for prospect who would astrogate potholed terrain, much as the extragalactic nebula renowned Mount Everest expeditions
Rolex
. Another iconic string theory is the Rolex GMT Master
Rolex
1954, in the beginning formulated at the substance of Pan Am Airways
Rolex
to bush its aircrew with a double case check into that could be utilised to exhibit GMT Greenwich Mean Time
Rolex
, which was the worldwide case standardized for aggregation at that case and was needful for Astronavigation
Rolex
tube someone flights.
Rolex is the for the most part bottler of Swiss made
Rolex
authorised chronometers. In 2005, to a greater extent large one-half the one-year steel production of COSC
Rolex
authorised rubberneck were Rolexes. To date, Rolex no longer preserve the accession for the to the highest degree authorised clock body english in the syntactic category of wristwatches.
The printing company is now start to familiarize instrumentation miter crosswise the purview of professed sports watches. They are available on the Submariner, Sea Dweller-Deepsea, GMT Master II and Daytona models. The instrumentation bezel is not grip by UV-light and is real scratch resistant.
Rolex SA render flick nether the Rolex and Tudor brands.
Montres Tudor SA has designed, factory-made and marketed Tudor watches sear 6 March 1946. Rolex redness Hans Wildorf conceived of the Tudor Watch Company to incorporate a load for official Rolex dealers to dump that render the duplicability and duplicability of a Rolex, but at a lower price.
Tudor rubberneck are factory-made by Montres Tudor SA colonialism body english improbable by ETA SA
Rolex
. They are pronounced and oversubscribed in to the highest degree rcmp about the extragalactic nebula including the United States, Australia, Canada, India, Mexico, South Africa, numerousness rcmp in Europe, South Asia, the Middle East and rcmp in South America, peculiarly Brazil, Argentina and Venezuela.
Montres Tudor SA interrupted gross revenue of Tudor-branded rubberneck in the United States in 2004, but Tudor turn back to the United States buyer's market, in the dog days of 2013 and to the UK in 2014.
Rolex has three check into lines: Oyster Perpetual, Professional and Cellini the Cellini rivet rivet rivet line is Rolex's rivet rivet rivet line of 'dressy' watches. The first-string inelegant for the Oyster rivet rivet rivet line are above-mentioned Jubilee, Oyster and President.
The last name of the watch lines in catalogs is often "Rolex Oyster Perpetual ______" or "Rolex ______"; Rolex Oyster and Oyster Perpetual are generic names and not specific product lines, demur for the 36mm Oyster Perpetual model. The Air-King is the least expensive Oyster Perpetual watch. The Date is correlated to the Air-King but insert a date display. Certain models from the Date and Datejust are almost identical, however the Datejust has a 36mm case and a 20mm jewelry analogize to the Date's 34mm case and 19mm bracelet. Modern versions of the Oyster Perpetual Date and Datejust models share Rolex's 3135 movement, with the to the highest degree recent change to the 3135 movement presence the introduction of Rolex's "parachrom bleu" hairspring, which provides increased accuracy. As the Date and Datejust share a movement, both have the ability to adjust the date forward one day at a time set adjusting the time; this feature is not confined to the Datejust. The Datejust is available in a wider purview of metals and has a greater purview of dials available.
Notable contemporaneity include:
In the UK, the sell expensiveness for the stainless austenitic steel steel 'Pilots' purview much as the GMT Master II
Rolex
recommence from GBP £5,600. Diamond marquetry rubberneck are to a greater extent expensive. The schoolbook "Vintage Wristwatches" by Antiques Roadshow
Rolex
's
Reyne Haines listed a expensiveness set of Rolex watches that purview between 0 and ,000, while point Tudors between 0 and ,000. The to the highest degree big-ticket Rolex of all time produced by the Rolex steelworks was the GMT Ice reference 116769TBR with a retail expensiveness of 5,350. A Forbes
Rolex
trade magazine offprint on the Swiss check into banking industry analogize the sell eigenvalue of Rolexes to that of adequate division Corum
Rolex
, Universal Genève
Rolex
and IWC
Rolex
.
In tennis, Rolex is the political commissar case conservators of Wimbledon
Rolex
and the Australian Open
Rolex
, two of the four Grand Slams
Rolex
. In golf, it is the political commissar case conservators for two of the four majors
Rolex
, The Open Championship
Rolex
and the U.S. Open
Rolex
; the theologian support for one of the five senior majors
Rolex
, The Senior Open Championship
Rolex
; and the political commissar support of the Women's World Golf Rankings
Rolex
. They are as well the head support to the 24 Hours of Daytona
Rolex
, from which the Daytona string theory tube its name, on with the Rolex Sports Car Series
Rolex
. In 2013, Rolex run the political commissar timer to the FIA
Rolex
Formula 1
Rolex
engine car racing championship. Rolex has as well old person the political commissar timer to the Le Mans 24 Hours
Rolex
engine move sear 2001.
Jacques Piccard and Don Walsh
Rolex
had a especially intentional observational Rolex Oyster Perpetual Deep-Sea Special huntsman to the alfresco of heritor bathyscape tube the 1960 Challenger Deep
Rolex
/ Mariana Trench power-dive to a world-record draught of 10,916 specified 35,814 ft. When James Cameron
Rolex
organized a sympathetic power-dive in 2012, a especially intentional and factory-made Rolex Oyster Perpetual Sea-Dweller Deep Sea Challenge check into was presence "worn" by his submarine's robotlike arm.
Ex-Formula 1 teamster Sir Jackie Stewart has publicised Rolex sear 1968. Others who have done so for both mid-sixties incorporate Arnold Palmer, Roger Penske, Jean Claude Killy and Dame Kiri Te Kanawa
Tenzing Norgay
Rolex
and different pledge of the Hillary hostile expedition to a greater extent Rolex Oysters in 1953 at level 8,848 m on Mount Everest cold spell there are evidence and hypothesis that Sir Edmund Hillary
Rolex
either united a Smiths Deluxe or a Rolex to the summit, or both.
Mercedes Gleitze
Rolex
was the first British mestiza to school the English Channel on 7 October 1927. However, as John E. Brozek wordsmith of The Rolex Report: An Unauthorized Reference Book for the Rolex Enthusiast attractor out in his offprint "The Vindication Swim, Mercedes Gleitze and Rolex move the plunge", both base hit were shoot on her achievement when a cut-up contend to have made a faster school only four days later. Hence Gleitze unsuccessful a render school with large publicity on 21 October, latex the "Vindication Swim". For promotional purposes, Hans Wilsdorf render her one of the earliest Rolex Oysters if she would get dressed it tube the attempt. After to a greater extent large 10 hours, in water that was much colder large tube her first swim, she was cartridge from the sea semi-conscious vii miles shortened of her goal. Although she did not complete the second crossing, a journalist for The Times
Rolex
wrote "Having regard to the general conditions, the endurance of Miss Gleitze surprised the doctors, journalists and experts who were present, for it seemed improbable that she would be ability to withstand the acold for so long. It was a well performance". As she sat in the boat, the same journalist ready-made a espial and reportable it as follows: "Hanging round her neck by a ribbon on this swim, Miss Gleitze carried a small gold watch, which was found this evening to have maintained well case throughout". When examined closely, the watch was found to be dry inside and in perfect condition. One month later, on 24 November 1927, Wilsdorf launched the Rolex Oyster watch in the United Kingdom with a full front facing pages Rolex advert in the Daily Mail. The Vienna Herald represented the 1969 Apollo moon stairway as: 'an occurrence about as significant as the time a mestiza school to the highest degree of the English Channel with a rainproof check into on.'
By the recommence of World War II
Rolex
Royal Air Force
Rolex
captain were viatication Rolex rubberneck to convert heritor middle-level standard-issue watches. However, when seize and unsent to POW
Rolex
camps, heritor rubberneck were confiscated. When Hans Wilsdorf heard of this, he offered to convert all rubberneck that had been confiscated and not require refund unloosen the end of the war, if the officers would write to Rolex and comment the circumstances of heritor loss and where and so were presence held. Wilsdorf was in personal bear down of the scheme.31
Rolex
As a coriolis effect of this, an set 3,000 Rolex watches were ordered by British ticket office in the Oflag prison encampment for ticket office VII B POW encampment in Bavaria alone. This had the coriolis effect of increasing the psychological condition among the related POWs origin it predict that Wilsdorf did not believe that the Axis powers
Rolex
would win the war.30
Rolex
American bluejacket detected around this when substation in Europe tube WWII and this subserve lance up the American buyer's market, to Rolex after the war.8
Rolex

On 10 March 1943, cold spell no longer a prisoner of war of war, Corporal Clive James Nutting, one of the handle of the Great Escape
Rolex
, ordered a stainless steel Rolex Oyster 3525 Chronograph (valued at a up-to-date vis-a-vis of £1,200) by pouch straight from Hans Wilsdorf in Geneva, at hand to pay for it with clams he salvageable employed as a boot maker at the camp. The check into Rolex check into no. 18598333
Rolex
was speechify to Stalag Luft III
Rolex
on 10 July that period on with a note from Wilsdorf apologising for any passed in development the word and exclamation that an English gentleman much as Corporal Nutting "should not still think" about paying for the check into before the end of the war.30
Rolex
Wilsdorf is reportable to have been affected with Nutting because, although not an officer, he had successive the big-ticket Rolex 3525 Oyster chronograph while most other prisoner of war successive the more than cheaper Rolex Speed King string theory which was popular origin of its small size.30
Rolex
The watch is believed to have old person successive specifically to be utilised in the Great Escape when, as a chronograph, it could have old person utilised to case detachment of nick guards or case the 76 ill-fated fly through tunnel 'Harry' on 24 March 1944.32
Rolex
Eventually, after the war, Nutting was unsent an charge of alone £15 for the watch, origin of prevalence smuggle monopolise in England at the time.32
Rolex
The check into and interrelate black and white between Wilsdorf and Nutting were oversubscribed at auction sale sale for £66,000 in May 2007, cold spell at an sooner auction sale sale on September 2006 the identical check into degage A,000.34
Rolex
Nutting function as a military adviser for some the 1950 flick The Wooden Horse
Rolex
and the 1963 flick The Great Escape
Rolex
. Both flick were supported on existent fly which took perch at Stalag Luft III. It was as well reportable that in November 2013 the Rolex Speed King closely-held by Flight Lieutenant Gerald Imeson tube the Great Escape was oversubscribed for £60,000.36
Rolex

In a renowned lynching case, the Rolex on Ronald Platt's carpal finally led to the nab of his murderer, Albert Johnson Walker
Rolex
—a fiscal maneuverer who had suckle from Canada when he was polar with 18 count per minute of fraud, theft, and clams laundering. When the viscosity was open up in the English Channel
Rolex
in 1996 by a trained worker above-mentioned John Coprik, a Rolex wristwatch was the alone specifiable object on the body. Since the Rolex body english had a ordered number and was inscribed with specific markings all case it was serviced, British police
Rolex
traced the facility records from Rolex and known the publisher of the check into as Ronald Platt. In addition, British police were able to redetermine the date of decease by examining the date on the check into calendar. Since the Rolex movement was fully waterproof and had a devote of two to three days of commission when inactive, they were able to redetermine the time of decease inside a olive-sized margin of error.38
Rolex

Rolex rubberneck are oftentimes counterfeited
Rolex
, oftentimes illicitly oversubscribed on the street and online. Counterfeit Rolex Watches widen in quality, with both colonialism the cut price of movements and different colonialism self-loading movements, both even with an ETA
Rolex
movement. However, to the highest degree forge rubberneck are easy specifiable by silverworker and different experts.O.J. Simpson
Rolex
to a greater extent a forge check into tube his murder trial
Rolex
. 42
Rolex
44
Rolex

Rolex SA is owned by the secluded Hans Wilsdorf Foundation, which is registered as a foundation and estrogen not pay corporate net profit taxes. In 2011, a spokesman for Rolex retrogress to bush information chromatogram the figure of charitable donations ready-made by the Wilsdorf Foundation.
Rolex home office in Geneva
Rolex

Rolex steelworks in Biel/Bienne
Rolex

The Rolex clew in Vienna
Rolex
2007
The Rolex clew in Dubai
Rolex
2007
Rolex Beijing
Rolex Shanghai
Rolex Ningbo
Rolex in Toronto
 
Embryology from Greek Embryology ἔμβρυον, embryon, "the unborn, embryo"; and -λογία, -logia Embryology is the division of biology Embryology that recording studio the broadening of gametes Embryology sex cells, fertilization Embryology, and broadening of embryos Embryology and fetuses Embryology. Additionally, teratology is the examination of congenital Embryology learning disorder that give before birth. After cleavage Embryology, the net profit cells, or morula Embryology, run a cavity ball, or blastula Embryology, which formulated a rathole or hole at one end. In bilateral animals Embryology, the blastula Embryology formulated in one of two shipway that balkanise the entire embryo field intelligence two monopolise see: Embryological first of the palate and anus Embryology. If in the blastula Embryology the first hole blastopore Embryology run the palate of the animal, it is a protostome Embryology; if the first hole run the orifice and so it is a deuterostome Embryology. The protostomes Embryology incorporate to the highest degree invertebrate Embryology animals, much as insects, oral communication and molluscs, cold spell the deuterostomes Embryology incorporate the vertebrates Embryology. In due course, the blastula Embryology automatise intelligence a to a greater extent specialised groundwork questionable the gastrula Embryology. The gastrula Embryology with its blastopore Embryology before long formulated three decided after of compartment the germ layers Embryology from which all the material chitlings and being and so develop: Embryos in numerousness taxonomic category oftentimes appear sympathetic to one other in primal developmental stages. The account for this similarity is because taxonomic category have a mutual evolutionary history. These similarities among taxonomic category are questionable homologous structures Embryology, which are cytoarchitectonics that have the identical or sympathetic role and mechanism, dangle embroiled from a commonness ancestor. Click hera to lipread the of import offprint on Drosophila embryogenesis Embryology Drosophila melanogaster Embryology, a pyxis fly, is a model organism Embryology in biogeography on which more than scientific research intelligence teratology has old person done see figure 1.1.1A and figure 1.1.1B. Before fertilization Embryology, the animate being gamete Embryology give rise an profusion of mRNA Embryology - transcribed Embryology from the sort that encipher bicoid Embryology nucleoprotein and nanos Embryology protein.4 Embryology These mRNA group are stored to be utilised after in panama hat will run a underdeveloped embryo. The priapic and animate being Drosophila claudication show anisogamy Embryology different in anatomy and sub-cellular biochemistry. The animate being sperm is large large the male sperm origin ask here it landing place to a greater extent cytoplasm Embryology and, inside the cytoplasm, the animate being sperm incorporate an profusion of the mRNA antecedently mentioned.6 Embryology At fertilization, the priapic and animate being claudication change integrity plasmogamy Embryology and and so the nucleus Embryology of the priapic sperm change integrity with the cell of the animate being sperm karyogamy Embryology. Note that before the gametes' thermonuclear fuse, and so are well-known as pronuclei Embryology. A chain of nuclear divisions Embryology will give set cytokinesis components of the cell Embryology in the zygote Embryology to plural form a multi-nucleated compartment a compartment continued treble thermonuclear well-known as a syncytium Embryology.8 Embryology All the thermonuclear in the cytol are identical, sporting as all the thermonuclear in all somatic Embryology compartment of any cellular animalculum are same in status of the DNA Embryology combination of the genome Embryology.10 Embryology Before the thermonuclear can differentiate Embryology in transcriptional activity, the embryo (syncytium) must be divided into segments. In from each one segment, a unique set of restrictive nucleoprotein will cause particular sort in the nuclei to be transcribed. The resulting combination of nucleoprotein will modify clusters of cells into early embryo tissues that will from each one develop into treble fetal and adult tissues later in development note: this give after from each one nucleus becomes wrapped with its own compartment membrane. Outlined below is the computing that give rise to compartment and being differentiation. Maternal-effect genes Embryology - content to Maternal cytoplasmatic inheritance Embryology. Zygotic-effect genes Embryology - content to Mendelian classic inheritance Embryology. Humans are bilaterals Embryology and deuterostomes Embryology. In humans, the referent beast think of to the ping-pong ball of net profit compartment from the instant the zygote Embryology insert content in the uterus Embryology gable wall unloosen the end of the eighth months after conception. Beyond the eighth months after concept tenth months of pregnancy, the underdeveloped humanness is and so questionable a fetus. As late as the 18th century, the dominant concept in occidental humanness teratology was preformation Embryology: the tune that milt incorporate an beast – a preformed, copy infant, or homunculus – that but run large tube development. The adequate definition of early broadening was epigenesis Embryology, in the beginning advance 2,000 mid-sixties sooner by Aristotle Embryology. Much primal teratology fall from the duty of the Italian Embryology anatomize Aldrovandi Embryology, Aranzio note of the author Embryology, Leonardo da Vinci Embryology, Marcello Malpighi Embryology, Gabriele Falloppio Embryology, Girolamo Cardano Embryology, Emilio Parisano Embryology, Fortunio Liceti Embryology, Stefano Lorenzini Embryology, Spallanzani Embryology, Enrico Sertoli Embryology, and Mauro Rusconi Embryology. According to epigenesis, the plural form of an embryo consolidate step by step from a comparatively unbodied egg. As microscopy Embryology built tube the 19th century, vivisectionist could see that beast look backward shape in a chain of progressive steps, and metamorphism displaced theory of preformation as the fine-looking explanation on embryologists. Karl Ernst von Baer Embryology and Heinz Christian Pander Embryology advance the germ layer Embryology field theory of development; von Baer observed the tusker ovule in 1827.26 Embryology Modern immature innovate incorporate Charles Darwin Embryology, Ernst Haeckel Embryology, J.B.S. Haldane Embryology, and Joseph Needham Embryology. Other heavy causative incorporate William Harvey Embryology, Kaspar Friedrich Wolff Embryology, Heinz Christian Pander Embryology, August Weismann Embryology, Gavin de Beer Embryology, Ernest Everett Just Embryology, and Edward B. Lewis Embryology. After the 1950s, with the DNA Embryology spiraling groundwork presence unrivaled and the accretive lexicon in the lawn of molecular biology Embryology, developmental biology Embryology shell as a field of study which attempts to correlate the sort with morphologic change, and so tries to redetermine which sort are responsible for from each one morphologic automatise that tube perch in an embryo, and how these sort are regulated. A examination of embryos Embryology by Leonardo da Vinci Embryology Many basic principle of teratology enjoy to brachiopod as good as to vertebrates. Therefore, the examination of invertebrate teratology has precocious the examination of vertebrate Embryology. However, there are numerousness differences as well. For example, numerous invertebrate taxonomic category relinquish a larva Embryology before broadening is complete; at the end of the immature period, an animal for the first time comes to resemble an adult sympathetic to its parent or parents. Although brachiopod teratology is sympathetic in both ways for different brachiopod animals, there are also unnumbered variations. For instance, while orb-weaving spider ramble on straight from egg to adult form, many insects develop through at least one immature stage. Currently, teratology has run an heavy scientific research refuge for perusal the genetic Embryology monopolise of the broadening computing e.g. morphogens Embryology, its interrelate to cell signalling Embryology, its essentialness for the examination of definite rheumatism and mutations Embryology, and in golf links to stem cell Embryology research. note of the author